With Penny at work, Bernadette and Amy decided to take girls' night to her. Too bad that meant Penny had to serve the wine instead of drink it.
After pouring their glasses, Penny told her crew that she was less than excited to go with Leonard to a Halloween party at the comic bookstore. Not only did she think the patrons were a tad creepy, but she also felt like she couldn't participate in conversations with Leonard and his friends since she has a limited knowledge of both comics and science.
Instead of letting Penny wallow in her own self-pity, Bernadette reminded the waitress that relationships are all about compromise. For example, Leonard takes an interest in Penny's acting career, even though he doesn't independently have an interest in casting calls and read-throughs.
If the pharmaceutical career doesn't pan out, Bernie could totally be an advice guru.