Mike & Molly stars Billy Gardell and Melissa McCarthy in a comedy about a working-class Chicago couple who had almost given up on love… and then found each other. Officer Mike Biggs is a good-hearted cop who works the beat with his fast-talking, wise guy partner, Officer Carl McMillan. When he least expected it, Mike met Molly Flynn, an instantly likeable fourth grade teacher with whom he's immediately smitten. Their relationship blossomed, and after realizing they were meant for one another, they got married.
Molly now has embarked on a career change as she has her sights set on being a writer. While attending the prestigious Iowa Writing Workshop, Molly sells her romance novel, but the excitement is short-lived as she now faces the pressures of meeting deadlines, taking notes from her opinionated publisher and dealing with her own insecurities as a writer. Mike and Molly live with her sexy older sister, Victoria, and their flirtatious, wine-loving mother, Joyce. Mike and Carl frequent a diner where they've become friends with Senegalese waiter, Samuel. Mike's other friend is Harry, his Overeater's Anonymous partner who he met at a Cubs game.
Often, Mike and Molly's relationship is complicated by interference from his mom, Peggy, and Carl's Grandma and Joyce's husband, Vince, who offer unsolicited advice on love. Mike, aside from living with his in-laws, has to deal with his partner dating Molly's sister, and supporting his wife while riding the roller coaster of being married to a published author.