4. Clay and Shelli
These two got together really quickly during Big Brother 17. Shelli Poole and Clay Honeycutt (aka Clelli) were inseparable until they were both up for elimination. Enter the infamous Shelli crying meme. Clay was the first to go, then Shelli was evicted the following week. But here's the catch: While Clay immediately went home, Shelli was the first Houseguest sent to the jury house once eliminated.
Watch every season of Big Brother on CBS All Access.