Sherlock Holmes vs. Jamie Moriarty
Sherlock Holmes threw a wrench in Jamie Moriarty's plans while he worked for Scotland Yard, so his #1 nemesis raised the stakes by tricking him. Going by the name Irene Adler, Moriarty seduced Holmes in order to study him. Even after Moriarty's arrest and imprisonment, she still pulls at Holmes’ heart strings—he continues to write letters to her because she is “the only person he can relate to."
Watch Elementary on CBS.