Ami Cusack was born and raised in Golden, Colorado, to Richard, a top gun pilot and explosives engineer, and Virginia, a former substitute English teacher and homemaker. After graduating Golden High School, she attended Rocky Mountain College of Art and Design in Denver. In 1992, while attending RMCAD, Cusack became one of the original six employees of a Golden-based nutritional company called Experiment and Applied Sciences. She started out by answering phones and by 1996 she became the company's charitable director. In 1998, (with over 350 employees), the company was sold and Cusack decided to travel for the next four years. Her travels led her to Australia, Thailand, Tahiti, Iceland, Japan and Africa.
Upon returning to the U.S., she took a job at a coffee shop, which she now considers "the greatest job in the world." She looks forward to being a mom and taking care of her family. She also is a nanny for a six-year-old. She is still very active in charities and has been named an Ambassador for the Colorado Chapter of the Make-A-Wish Foundation.
In 1996, she lost her 18-year-old younger brother, Kyle, to a drunk driver. Her mother now conducts motivational speaking to high school students about the consequences of drinking and driving.
Cusack is currently single. Her birth date is January 25, 1973.