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Academy Award winner Mira Sorvino, Academy and Golden Globe Award winner Anjelica Huston and Stephen Dorff star in this nail-biting tale of action and intrigue about members of an elite undercover team who race against time to locate the source of a deadly virus threatening the lives of millions of Americans.

Former secret agent and disease specialist Colonel Jonathan Smith works for Covert One, a top-secret American intelligence agency made up of political and technical experts. Their brief: to fight corruption and conspiracy at the highest and most dangerous levels of society.

When three US soldiers stationed in Afghanistan succumb to an unknown Ebola-like virus, the United States Army Medical Research Institute for Infectious Diseases (USAMRIID) moves into action. As the death toll mounts and the virus spreads, Smith's fiancée, Dr. Sophie Amsden, succumbs to the illness. Smith soon discovers evidence that Sophie's death was not an accident. The pandemic was planned.