Real-Life Men Of Science Who Made "One Giant Leap" Into The Big Bang Theory

For as much shenanigans the gang gets into on The Big Bang Theory, we sometimes forget that they're among some of the most brilliant minds on the planet. So, it stands to reason that they would occasionally run into real-life scientists, astronauts, and tech moguls. Let's take a look back at some of the notable men of science who have crossed paths with our lovable Big Bang characters. Watch all-new episodes of The Big Bang Theory on Thursdays at 8/7c on CBS and CBS All Access.

It's a cameo compound for the ages!

1. It's a cameo compound for the ages!

For as many shenanigans the gang gets into on The Big Bang Theory, we sometimes forget that they're among some of the most brilliant minds on the planet. So, it stands to reason that Sheldon (Jim Parsons), Leonard (Johnny Galecki), Howard (Simon Helberg), and Raj (Kunal Nayyar) would occasionally run into real-life scientists, astronauts, and tech moguls.

STREAM: Full Episodes Of The Big Bang Theory On CBS All Access

As the latest season of The Big Bang Theory continues, let's take a look back at some of the notable men of science who have crossed paths with our lovable Big Bang characters.

Watch all-new episodes of The Big Bang Theory on Thursdays at 8/7c on CBS and CBS All Access.
Stephen Hawking

2. Stephen Hawking

The late, great theoretical physicist Stephen Hawking guest starred a number of times on The Big Bang Theory as himself. After his first appearance, he become a mentor to Sheldon, both personally and professionally.
Elon Musk

3. Elon Musk

Howard meets Tesla founder Elon Musk, quite by chance, while serving Thanksgiving dinner to the homeless. What a caring guy!
Bill Nye

4. Bill Nye

When Professor Proton (Bob Newhart) asks Leonard for advice instead of Sheldon, the latter seeks revenge by rubbing elbows with the "Science Guy" himself, Bill Nye.
Buzz Aldrin

5. Buzz Aldrin

While none of the guys actually meet Buzz Aldrin, they do see the legendary astronaut handing out candy to trick-'r-treaters on Halloween in a video.
Steve Wozniak

6. Steve Wozniak

When Sheldon meets—or rather e-meets—"The Great and Powerful Woz" via his own "Shelbot" invention, he asks the Apple co-founder to sign his Apple II computer.
George Smoot

7. George Smoot

During a conference in San Francisco, Sheldon and the guys encounter Nobel laureate Dr. George Smoot, who conducts a keynote lecture at the event.
Ira Flatow

8. Ira Flatow

Former Newton's Apple host and science personality Ira Flatow has made several guest appearances on The Big Bang Theory, often interviewing the guys about their latest scientific exploits on his radio show.
Mike Massimino

9. Mike Massimino

Buzz Aldrin isn't the only astronaut to pop up on The Big Bang Theory! Space Shuttle veteran Dr. Michael J. Massimino accompanies Howard aboard a Soyuz craft on Expedition 31.