The 20 Most Savage Big Brother Blindsides

These Houseguests didn't see this coming.

These are the biggest Big Brother blindsides ever

These are the biggest Big Brother blindsides ever

In Big Brother, Julie Chen warns Houseguests to expect the unexpected. And every season, countless players are blindsided inside the house.

It doesn’t matter if it’s a shocking eviction or a twist that totally rocks the house, blindsides are a major part of the Big Brother game.

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But which of these jaw-dropping moments turned the house upside down? These are the 20 biggest blindsides in the Big Brother house.

Big Brother 21: Nick is betrayed by the Six Shooters

Big Brother 21: Nick is betrayed by the Six Shooters

The biggest blindside of Big Brother 21 happened during Nick Maccarone's reign as HoH. He went through the week unaware that his alliance had turned on him, and quietly seethed on Eviction Night when the House voted 6-4 to evict Cliff Hogg over his preferred target, Nicole Anthony.

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Big Brother 7: Janelle votes Will out

Big Brother 7: Janelle votes Will out

After being aligned with Will Kirby for the majority of Big Brother 7, Janelle Pierzina eventually evicted her ally over Erika Landin.

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Don't miss all-new episodes of Big Brother on Sundays at 8/7c, and Wednesdays and Thursdays at 9/8c—always on CBS and CBS All Access.

Then, be sure to check out the Big Brother Live Feeds—exclusively available through CBS All Access—for a 24/7 peek inside the BB house.