After graduating from Juilliard in 2015, Mary Wiseman quickly went on to star opposite Keira Knightley in the Broadway production of Therese Raquin. Recently, Wiseman starred in the world premiere of Romance Novels for Dummies at the Williamstown Theatre Festival. Prior to that, she starred in the Williamstown Theatre Festival's production of Off the Main Road opposite Kyra Sedgwick as well as in the Off-Broadway, Obie Award-winning production of An Octoroon, in which her performance was described as "delicious" and "comically inspired."
For television, Wiseman appeared in the Netflix series Longmire and The Characters and in Hulu's Difficult People.
Currently, Wiseman can be seen opposite Zach Galifianakis in the second season of the FX series Baskets. Recently, she wrapped a starring role in the new Off-Broadway production of The Skin of Our Teeth at the Theatre for a New Audience in Brooklyn, New York.